بررسی تأثیر تجویز ویتامین بر گرگرفتگی زنان یائسه

  Background: Menopause is one of the steps in women's life which accompany with a lot of problems. The most common of these problems is hot flashes. Many treatments that suggested for hot flashes were not accepted by women due to side effect of ineffectiveness.   Aims: This study was developed to assess the efficacy of vitamin E, which is an inoffensive drug, for the alleviation of hot flashes in menopausal women.   Material & Methods: Sixty menopause women suffering from hot flashes were selected and divided into two groups using randomized sampling method. Afterwards the first group received 400 IU vitamin E daily while the other group received placebo for four weeks. In this study cross over design was used. In order to eliminate the carry over effect one week washout was considered. Then the drugs were reversed for each group and the study was continuing for another four weeks. In each group hot flashes frequency, hot flashes severity and maturation index of vaginal cells before treatment, after the first period of treatment and after second period of treatment compared with each others. The result included that: The difference of hot flashes frequency and hot flashes severity before treatment and at the end of first treatment period and also before treatment at the end of second treatment period were highly significant in both groups. It is noticeable that there were a significant difference between hot flashes frequency and hot flashes severity at the end of first and second treatment period in both groups.   Results: There were no significant differences between percentage of parabasal and superficial cells of vaginal sample before treatment and at the end of first treatment period and also before treatment, and at the end of second treatment period in but groups.   Conclusion: The evaluation of the results indicated that but vitamin E and placebo could alleviate the hot flashes symptoms but the effect of vitamin E comparing with placebo is more significant.